
14-3-3 inhibitor BV2
CAS No. 302602-92-2
14-3-3 inhibitor BV2 ( —— )
产品货号. M13948 CAS No. 302602-92-2
一种 14-3-3 蛋白质-蛋白质相互作用的新型非肽抑制剂,可促进表达 wt Bcr-Abl 构建体或 T315I 突变的细胞凋亡。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称14-3-3 inhibitor BV2
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述一种 14-3-3 蛋白质-蛋白质相互作用的新型非肽抑制剂,可促进表达 wt Bcr-Abl 构建体或 T315I 突变的细胞凋亡。
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产品描述A novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation; induces significant dose-dependent reduction of reproductive integrity of Ba/F3 cells expressing the wt and T315I-mutated Bcr-Abl with LD50 of 1.04 and 1.47 uM, respectively; promoted c-Abl release from 14-3-3σ, abolishes c-Abl expression in the cytoplasm, but has no influence on 14-3-3σ levels, induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib.
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体外实验——
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体内实验——
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同义词——
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通路Others
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靶点14-3-3 Protein
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受体14-3-3 Protein
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研究领域——
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适应症——
化学信息
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CAS Number302602-92-2
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分子量395.371
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分子式C20H17N3O6
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)C3=C(C=CC(=C3)C(=O)O)C(=O)O
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化学全称2-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)carbamoyl)terephthalic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mancini M, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):596-604.
2. Mohammad DK, et al. Mol Cell Biol. 2013 Aug;33(16):3214-26.
3. Gómez-Suárez M, et al. Cell Death Differ. 2016 Jun;23(6):1060-72.
4. Valensin D, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):894-898.